Hi- Is there any way you can post a photo of what these look like? Guinea pigs can get all kinds of different problems with their skin, including ringworm. Unfortuantely, if it is ringworm, worming them will not work because ringworm is actually a fungus. If that is what it is you can use one of the products made for human athlete's foot such as Lamisil or Tolfinate (I hope I'm spelling that right) There are a few different anti-fungal medications available over the counter. Some of them work in a month and some in a week so be sure to read the labels. I have used Lotrimin liquid with good results. I would recommend a liquid over a cream or ointment because it is less messy. There is another product that is worth a shot too. It is called Mane n Tail Pro-tect and it is a shampoo. You would have to shampoo the pigs every week or so for a month but it works for all kinds of skin problems including fungus, bacterial infections and other opportunistic infections. It is made for horses. Just read and follow the label. If you can start with that I would because you don't have to determine what is causing the problem first, since it is good for so many different problems. The other option ifyou have a good vet available near you is to have them do a skin scraping to let you know exactly what the problem is and then target it specifically. If they were mine, I'd likely start with the shampoo and go from there. Make sure that the shampoo you get is Pro-tect because Mane n Tail makes a bunch of differnt ones. Good luck and let me know how it goes or if you have more questions.